Download PDF by John S. Bradley MD, John D. Nelson MD Emeritus, Dr.: 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th

By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Pablo J Sanchez MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach

ISBN-10: 1581106548

ISBN-13: 9781581106541

This bestselling and standard source on pediatric antimicrobial remedy offers immediate entry to trustworthy ideas for remedy of all infectious illnesses in children.

For each one sickness, the authors offer a remark to aid wellbeing and fitness care prone choose the simplest of all antimicrobial offerings. The inquiring healthcare professional can instantly hyperlink to the facts for the advice within the booklet or cellular model. Drug descriptions hide all antimicrobial brokers on hand this day and comprise entire information regarding dosing regimens.

In reaction to growing to be issues approximately overuse of antibiotics, the publication contains guidance on while to not prescribe antimicrobials.

Key beneficial properties in nineteenth Edition!

- up to date information about the power and the extent of proof for all therapy thoughts

- New bankruptcy on antibiotic treatment for overweight kids

- New bankruptcy on antimicrobial prophylaxis and prevention of symptomatic an infection

- contains remedy of parasitic infections and tropical drugs.

- up to date anti-infective drug directory, whole with formulations and dosages.

- Balanced info on safeguard, efficacy and tolerability with info on charges and availability of gear

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Additional info for 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition

Example text

Duration of therapy dependent on causative organism and normalization of erythrocyte sedimentation rate and C-reactive protein; minimum for osteomyelitis 3 wk and arthritis therapy 2–3 wk if no organism identified (AIII). Surgical drainage of pus (AIII); physical therapy may be needed (BIII). – Empiric therapy60,61 Nafcillin/oxacillin IV (or vancomycin if MRSA is a concern) AND cefotaxime or gentamicin IV, IM (AIII) 22 — Chapter 5. Antimicrobial Therapy for Newborns A. Recommended Therapy for Selected Newborn Conditions (cont) – Coliform bacteria (eg, Escherichia coli, Klebsiella sp, Enterobacter sp)61 For E coli and Klebsiella: cefotaxime OR gentamicin OR ampicillin (if susceptible) (AIII) For Enterobacter, Serratia, or Citrobacter: ADD gentamicin IV, IM to cefotaxime or ceftriaxone, OR use cefepime or meropenem alone (AIII) Ceftriaxone IV, IM OR cefotaxime IV x 7–10 d (AII) – Gonococcal arthritis and tenosynovitis10–13,61 Meropenem for ESBL-producing E coli and Klebsiella (AIII) Pip/tazo or cefepime are alternatives for susceptible bacilli (BIII) Cefotaxime is preferred for infants with hyperbilirubinemia MSSA: oxacillin/nafcillin IV (AII) MRSA: vancomycin IV (AIII) – Group B streptococcus61 Ampicillin or penicillin G IV (AII) – Haemophilus64 Ampicillin IV, OR cefotaxime IV, IM If ampicillin-resistant Start with IV therapy, and switch to oral therapy when clinically stable.

Reliable follow-up important if only a single dose of benzathine penicillin given. – Normal physical exam, Benzathine penicillin G 50,000 units/kg/dose IM in a single serum quantitative dose (AIII) nontreponemal serologic titer ≤ maternal titer: mother treated adequately during pregnancy and >4 wk before delivery; no evidence of reinfection or relapse in mother No evaluation required. Some experts would not treat but provide close serologic follow-up. 2012–2013 Nelson’s Pediatric Antimicrobial Therapy — 29 – Normal physical exam, Evaluation abnormal or not done completely: aqueous serum quantitative penicillin G 50,000 U/kg/dose q12h (day of life 1–7), q8h nontreponemal sero(>7 days) IV OR procaine penicillin G 50,000 U/kg IM logic titer ≤ maternal q24h for 10 days (AII) titer and maternal Evaluation normal: aqueous penicillin G 50,000 U/kg/dose treatment was q12h (day of life 1–7), q8h (>7 days) IV OR procaine (1) none, inadequate, penicillin G 50,000 U/kg IM q24h for 10 days; OR or undocumented; benzathine penicillin G 50,000 units/kg/dose IM (2) erythromycin, in a single dose azithromycin, or other non-penicillin regimen; or (3) <4 wk before delivery Condition Therapy (evidence grade) See Table 5B for Neonatal Dosages Comments – Normal physical exam, No treatment serum quantitative nontreponemal serologic titer ≤ maternal titer, and the mother’s treatment was adequate before pregnancy No evaluation required.

Lymphadenitis (see Adenitis, acute bacterial) (S aureus, including CA-MRSA; synonyms: tropical myositis, pyomyositis) 40 — Chapter 6. Antimicrobial Therapy According to Clinical Syndromes A. SKIN AND SOFT TISSUE INFECTIONS (cont) Empiric therapy: ceftazidime 150 mg/kg/day IV div q8h, or cefepime 150 mg/kg/day IV div q8h or cefotaxime 200 mg/kg/day IV div q6h AND clindamycin 40 mg/kg/day IV div q8h (BIII); OR meropenem 60 mg/kg/day IV div q8h; OR pip/tazo 400 mg/kg/day pip component IV div q6h (AIII) ADD vancomycin for suspect CA-MRSA, pending culture results (AIII) Group A streptococcal: penicillin G 200,000–250,000 U/kg/day div q6h AND clindamycin 40 mg/kg/day div q8h (AIII) Mixed aerobic/anaerobic/gram-negative: meropenem or pip/tazo AND clindamycin (AIII) Aggressive emergent wound debridement (AII) Add clindamycin to inhibit synthesis of toxins at the ribosomal level (AIII).

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2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition by John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Pablo J Sanchez MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach


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