By P. P. Pandolfi (auth.), Pier Paolo Pandolfi MD, Ph.D., Peter K. Vogt Ph.D. (eds.)
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Additional resources for Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy
J. McConnell · J. D. Licht 46. Licht JD, Shaknovich R, English MA, Melnick A, Li JY, Reddy JC, Dong S, Chen SJ, Zelent A, Waxman S (1996) Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)associated acute promyelocytic leukemia. Oncogene 12:323–336 47. Lin RJ, Nagy L, Inoue S, Shao W, Miller WH Jr, Evans RM (1998) Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391:811–814 48. Reference deleted in proof 49.
This strongly supports the hypothesis that loss of PLZF leads to unrestricted exit from quiescence, diminishing the stem cell pool and causing premature progenitor loss due to the limited proliferative potential of committed progenitor cells. This effect of PLZF might be relevant to APL. Loss of one allele of PLZF might lead to deregulation of the stem cell; a decision in favor of proliferation may be made rather than quiescence. In this regard we note that while PLZF is a growth suppressor, the RARα-PLZF oncoprotein, which can bind to many of the same DNA-binding sites of wildtype PLZF, activates genes that PLZF represses and induces a myeloproliferative disease in mice.
Blood 91:2634–2642 25. Reference deleted in proof 26. Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (2003) VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene 22:4035–4046 27. Hay RT (2005) SUMO: a history of modiﬁcation. Mol Cell 18:1–12 28. He L, Bhaumik M, Tribioli C, Rego EM, Ivins S, Zelent A, Pandolﬁ PP (2000) Two critical hits for promyelocytic leukemia.
Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy by P. P. Pandolfi (auth.), Pier Paolo Pandolfi MD, Ph.D., Peter K. Vogt Ph.D. (eds.)