By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)
After 3 volumes on adenoviruses in 1995 the previous years have obvious swift development within the box of adenovirus study. furthermore, adenoviruses have attracted massive curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity bargains with the immune method, oncogenesis and gene remedy.
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Extra resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy
Genes Dev 15:3104-3117 Raska Jr K (1995) Functional domains of adenovirus EIA oncogenes which control interactions with effectors of cellular immunity. Curro Topics in Microbiol. & Immunol199 (part III):131-148 Rotem-Yehudar R, Groettrup M, Soza A, Kloetzel PM, Ehrlich R (1996) LMP-associated proteolytic activities and TAP-dependent peptide transport for class I MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12. J Exp Med 183:499-514 Rotem-Yehudar R, Winograd S, Sela S, Coligan JE, Ehrlich R (1994) Down-regulation of peptide transporter genes in cell lines transformed with the highly oncogenic adenovirus 12.
I (Ad'O) ~ous E3-0RFs 'nsubge.... 7K Subgroup A 1,>¥""",.. I[I:: · :l --Z,··:: .. 8K Subgroup E I" """"".. 5K 147K C . encodng transmembr8J'1e proleins present in iiIIl or in the ma;on:y of subgenera . ORF. encooog cylooolic proteins 0 Fig. 1 E3 region coding capacity of representative members of Ad subgenera A-F. Open reading frames (ORFs) are indicated as bars and are drawn to scale. The shading code is depicted below the figure. ORFs encoding transmembrane proteins are indicated by filled boxes and bold characters, and ORFs encoding cytosolic proteins are represented by open boxes.
Int J Oncol 5:425-444 Blair GE, Hall KT (1998) Human adenoviruses: evading detection by cytotoxic T lymphocytes. Sem Virol8:387-397 Boulanger PA, Blair GE (1991) Expression and interactions of human adenovirus oncoproteins. Biochem J 275:281-299 Brockmann D, Feng L, Kroner G, Tries B, Esche H (1994) Adenovirus type 12 early region lA expresses a 52R protein repressing the trans-activating activity of transcription factor c-jun/AP-l. Virology 198:717-723. Brockmann D, Schafer D, Kirch H-C, Esche H (1996) Repression of c-Jun-induced mouse major histocompatibility class I promoter (H-2Kb ) activity by the adenovirus type 12-unique 52R EIA protein.
Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy by G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)