By Cyril Fisher (auth.)
Soft tissue tumors are a wide and heterogeneous staff of tumors and pseudotumors with a spectrum of habit from benign to frankly malignant. This Atlas of soppy Tissue Tumor Pathology offers an summary of reactive, pseudoneoplastic, benign and intermediate neoplasms, sarcomas and comparable stipulations coming up in subcutaneous and deep delicate tissues. Emphasis is put on microscopic appearances with correlation with gross diagnostic findings the place suitable. additionally, the immunohistochemical and molecular genetic beneficial properties of the most important tender tissue tumor subtypes are provided. This compendium of sentimental tissue tumors illustrates nearly all of ailments you are going to come upon in surgical pathology.
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Extra info for Atlas of Soft Tissue Tumor Pathology
Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet. 1998;18:184–7. Loh ML, Ahn P, Perez-Atayde AR, Gebhardt MC, Shamberger RC, Grier HE. Treatment of infantile fibrosarcoma with chemotherapy and surgery: results from the Dana-Farber Cancer Institute and Children’s Hospital, Boston. J Pediatr Hematol Oncol. 2002;24:722–6. Marino-Enriquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, et al. Epithelioid inflammatory myofibroblastic sarcoma: an aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.
3 Benign Fibroblastic and Myoﬁbroblastic Lesions A large group of relatively common soft tissue tumors are composed of a mixture of fibroblasts and myofibroblasts. Fibroblasts are slender cells with elongated tapered or serpiginous nuclei and little cytoplasm. Myofibroblasts tend to be plumper and have oval nuclei, each with a small distinct nucleolus, and variable amounts of amphophilic cytoplasm according to the functional state of the cells. Both have contractile and (stromal) secretory properties and can modulate into fibroblasts.
The storiform-pleomorphic malignant fibrous histiocytoma became the most frequently diagnosed sarcoma in all sites in adults, and rarer giant cell and inflammatory, myxoid, and angiomatoid variants were described. However, newer investigative techniques revealed that many such neoplasms might be categorized specifically as pleomorphic rhabdomyosarcomas or liposarcomas, dedifferentiated liposarcomas, melanomas, or poorly differentiated carcinomas. The apparently undifferentiated remainder were not histiocytic but comprised pleomorphic fibroblastic and myofibroblastic cells.
Atlas of Soft Tissue Tumor Pathology by Cyril Fisher (auth.)